Malegra 50 mg is typically taken orally, as needed, approximately 30 minutes to 1 hour before sexual activity. The medication is effective in response to sexual stimulation, and its effects typically last for about 4 hours. Malegra 50  is a medication used to treat erectile dysfunction (ED) in men. It contains sildenafil citrate, which is a phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil works by increasing blood flow to the penis during sexual stimulation, helping men achieve and maintain an erection.