비아그라는 발기조직인 음경해면체에 존재하여 cGMP를 분해시키는 제5형 포스포다이에스테라제 라는 효소를 억제함으로서 음경해면체에서 생성되는 산화질소 (NO)의 작용을 강화하여 정맥동의 확장을 지속시킴으로서 발기부전에 치료효과를 보인다.
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