Take the tablet orally with a glass of water. Tazzle 20 mg can be taken with or without food. However, a high-fat meal might delay its absorption and onset of action. Tadalafil typically starts working within 30 to 60 minutes of ingestion. One of the main benefits of Tazzle 20 mg is its long duration of action, which can last up to 36 hours. This allows for a greater window of opportunity for sexual activity compared to other ED medications.