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Tramadol is an analgesic medication that acts centrally, and it is regarded as one of the weak opioids. It uses a "dual mechanism": first of all, tramadol affects opioid receptors, and at the same time it affects the processes of serotonin and norepinephrine reuptake in the nervous system. Such a "dual mechanism" allows tramadol to provide pain relief in cases that cannot be solved using regular painkillers that are not capable of such an effect.

Tramadol is located between strong and weak analgesics. It is stronger than, for example, ibuprofen or diclofenac, but it is weaker than morphine or fentanyl. Thus, tramadol is often prescribed when NSAIDs do not work, but prescription of strong opioids is not needed yet. In the analgesic ladder created by WHO, tramadol is usually the second step in case of moderate pain.

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