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Nucynta (tapentadol) is indicated for the management of Pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Neuropathic pain associated with diabetic peripheral neuropathy (DPN) severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Prolonged-release tapentadol (Nucynta ER) is for the 24-hour treatment of pain that is not controlled by other medications.

This can cause life-threatening withdrawal symptoms in the baby after he or she is born. Tell your doctor if you notice severe sleepiness or slow breathing in your baby. Do not give tapentadol to your baby. You should not use tapentadol if you are allergic to it or if you have: severe asthma or breathing problems; stomach or intestinal obstruction, including paralytic ileus. Tell your doctor if you have ever had: breathing problems, sleep apnea; head injury, brain tumor, or seizures; alcohol or drug abuse; mental illness; urinary problems; liver or kidney disease; or problems with your gallbladder, pancreas, thyroid, or adrenal glands.