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Tapentadol is a centrally acting analgesic medication used primarily for the management of moderate to severe acute pain. It is chemically related to opioid analgesics but has a unique dual mechanism of action, combining mu-opioid receptor agonism and norepinephrine reuptake inhibition.

Tapentadol works by activating mu-opioid receptors in the central nervous system to reduce pain perception, similar to traditional opioid medications like morphine. However, it also inhibits the reuptake of norepinephrine, a neurotransmitter involved in pain modulation, which may contribute to its analgesic effects.

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