Tapentadol is a centrally acting opioid analgesic used primarily for the management of moderate to severe pain. It works by binding to opioid receptors in the brain and spinal cord, inhibiting the transmission of pain signals and altering the perception of pain.

Tapentadol is unique compared to traditional opioids because it not only acts as a mu-opioid receptor agonist but also inhibits the reuptake of norepinephrine, which may contribute to its analgesic effects while potentially reducing the risk of certain opioid-related side effects, such as respiratory depression and constipation.

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